If you were to ask a group of people why brain cancer would rise to the surface, the various answers given will show that there is no concrete reasoning. Enzymes could play a role in the matter, as it's been said that they can trigger and make this condition progress. This is especially true when focusing on glioblastoma, the most common and aggressive type of cancer in this regard. Focusing on enzymes, though, what can be done in order to stop them in their tracks?
According to a Futurity article, it appears as though this will be the case. A new "backdoor" approach has been seen in order to help this form of brain cancer. Basically, it will be able to halt an enzyme that is responsible for the progression of glioblastoma, which is reason enough for organizations along the lines of Voices against Brain Cancer to bring their focus on it. What are the specifics behind this, though, and how was the study carried through? The details are quite interesting, to say the least.
The enzyme that was focused on was referred to as phospholipase D, though it's not just in the realm of brain cancer that this has been seen. Other types of cancers like breast and gastric have been correlated to it as well, so it goes without saying that it has seen a great deal of attention in the way of science. PLD is also responsible for the regulation of Akt, another enzyme that is integral to cancer growth. There are many more details than I would have expected to uncover before reading this report.
PLD was given a tremendous amount of focus during a study with mice, each of the subjects afflicted with glioblastoma. One would assume that simply locking Akt would aid the problem but, as the article detailed, it is a course of action that stands a great chance of creating strong actions in the body. An exaggerated immune response, for example, could come to the surface. This subject deserves focus, without question, but care is another element that shouldn't be ignored.
Professor Craig Lindsley spoke about the concept of the isoform related to Akt being targeted without bringing any kind of harm to the patient. Keep in mind that if Akt is not activated, the cancerous cells in the body die out, which is especially worthy of note when considering that the patient is not harmed as a result. Safety should be top priority when talking about any field of research. The focus given on certain enzymes, in my opinion, is one that can open up greater possibilities.
According to a Futurity article, it appears as though this will be the case. A new "backdoor" approach has been seen in order to help this form of brain cancer. Basically, it will be able to halt an enzyme that is responsible for the progression of glioblastoma, which is reason enough for organizations along the lines of Voices against Brain Cancer to bring their focus on it. What are the specifics behind this, though, and how was the study carried through? The details are quite interesting, to say the least.
The enzyme that was focused on was referred to as phospholipase D, though it's not just in the realm of brain cancer that this has been seen. Other types of cancers like breast and gastric have been correlated to it as well, so it goes without saying that it has seen a great deal of attention in the way of science. PLD is also responsible for the regulation of Akt, another enzyme that is integral to cancer growth. There are many more details than I would have expected to uncover before reading this report.
PLD was given a tremendous amount of focus during a study with mice, each of the subjects afflicted with glioblastoma. One would assume that simply locking Akt would aid the problem but, as the article detailed, it is a course of action that stands a great chance of creating strong actions in the body. An exaggerated immune response, for example, could come to the surface. This subject deserves focus, without question, but care is another element that shouldn't be ignored.
Professor Craig Lindsley spoke about the concept of the isoform related to Akt being targeted without bringing any kind of harm to the patient. Keep in mind that if Akt is not activated, the cancerous cells in the body die out, which is especially worthy of note when considering that the patient is not harmed as a result. Safety should be top priority when talking about any field of research. The focus given on certain enzymes, in my opinion, is one that can open up greater possibilities.
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If you'd care to learn more about feats to elevate awareness for brain cancer, please go to Voices against Brain Cancer.